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The brain produces natural morphine-like substances called endorphins (endogenous + morphine) and enkephalins (meaning in the head).
Like morphine, these substances bind to opiate receptors in the CNS, moderating pain, relieving anxiety, and producing a sense of well being. The "high" experienced by joggers may be due to endorphins and enkephalins.
adopted from The human body in health and illness, Herlihy & Maebius